The newly-established Municipality of Topeiros owes its name to a city which existed on The Egnatia Road, during the Roman Ages, in the same area in which the Municipality extends today.

Approaching the bridge over the Nestos river, in the area between the villages of Toxotes and Paradeisos, 14 Km west of Xanthi, you can see the remains of the ancient city of Topeiros, where monuments of old Christian and Byzantine ages, mostly parts of Churches and Monasteries, have been revealed and conserved.

It was established in the 1st century A.C. and it was the Bishop' s See from the 5th to 8th century. Recent clear evidence for the Bishopric of Topeiros comes from the 1st early Byzantine Ages, specifically from 4th and 5th century. As a consequence So, Bishop's names are reported in the records of the Third and Forth Ecumenical Synods. At the end of the 4th century, Topeiros gained distinction from Traianoupoli's Metropolitan Bishop, under whose domination remained for at least 900 ages.

During the 2nd century A.C. the city of Topeiros had its own coins (Proof of self rule and wealth). With the division of the Roman Empire into East and West, the area of Xanthi with the city Topeiros as capital, belongs to the East Empire and it is its western boundary.

In 549 A.C. during the Justinian Empire the city was conquered by the Slavs, who totally destroyed it. 2 years later, Justinian rebuilt it and surrounded it with stronger walls (the remains of these awlls are across the army camp of Toxotes).

The city has historical presence until 812 A.C. when destroyed by the Bulgarian Tzar "Croumo".